The April 28, 2026 partial Schedule III order (91 Fed. Reg. 22714) marks the most significant federal regulatory shift in cannabis policy in seventeen years.¹ For the first time, qualifying state-licensed medical cannabis operators have a clear pathway to 280E relief and expedited DEA registration. Yet the dominant public response from many legacy advocacy groups … Continue reading The Federal Compliance Cliff: How Schedule III May Threaten Small Cannabis Operators Before 280E Relief Arrives