Excerpted from this Psychedelic Times article:
A study recently published in Harm Reduction Journal investigated whether patients with a psychotic disorder would accept smoking pharmaceutical cannabis variants that are less harmful than high-potency cannabis.

Results
There were very few undesired side effects from smoking the joints in the study. Psychotic-like symptoms were not observed at all, although occasional bouts of transitory nausea and dizziness did occur.
Patients reported that they accepted the pharmaceutical joints, however they did prefer their own cannabis. The main complaint the patients had about the medicinal variants was that they were significantly weaker. Apparently they didn’t taste as good either.
When asked if they would be willing to replace their own high-potency cannabis with one of the two medicinal variants, the patients did not provide clear answers. But they didn’t shut down the idea outright, offering that any potential transition would depend on two things: the experience of using the pharmaceutical cannabis on a long term basis and the options for being financially reimbursed.
While this was a small study, it found that cannabis-smoking patients with psychotic disorders appear to be willing to consume less THC and/or increase the amount of CBD, potentially even converting to medicinal variants. This would reduce the harms of consuming cannabis for this population, and further studies would need to be conducted in an effort to corroborate these findings.
Read the full study in the Harm Reduction Journal click here. Below is this study summary. I’m not a doctor or scientist.

Acceptance of pharmaceutical cannabis substitution by cannabis using patients with schizophrenia
- Jan van AmsterdamEmail authorView ORCID ID profile,
- Jojanneke Vervloet,
- Gerdien de Weert,
- Victor J. A. Buwalda,
- Anna E. Goudriaan and
- Wim van den Brink
- Received: 5 June 2018
- Accepted: 4 September 2018
- Published: 20 September 2018
Abstract
Background
Cannabis-smoking patients with a psychotic disorder have poorer disease outcomes than non-cannabis-smoking patients with poorest outcomes in patients smoking high-potency cannabis (HPC) containing high Δ9-tetrahydrocannabinol (THC) and low cannabidiol (CBD). Quitting cannabis smoking or substitution of HPC by cannabis variants containing less THC and/or more CBD may benefit these patients. The present study explores whether daily HPC-smoking patients with schizophrenia accept smoking such variants.
Methods
Twelve male patients were asked to smoke on six different occasions one joint: on two occasions, the cannabis they routinely smoke (HPC; not blind), and blind in random order; on two occasions, cannabis containing low THC and no CBD; and on two occasions, cannabis containing low THC and high CBD.
Results
Both substitute variants were appreciated, but patients preferred the HPC they usually smoked. The effect of the low THC/high CBD variant was reported by 32% to be too short and by 36% to be not strong enough, whereas this was reported by 5% and 64%, respectively, for the low THC cannabis variant.
Conclusions
Based on these findings, a larger and longer study on the efficacy of cannabis substitution treatment in HPC-smoking patients with schizophrenia seems feasible and should be considered.
Trial registration
2014-005540-17NL. Registered 22 October 2014, 2014-005540-17NL 20141215 CTA.xml

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